ESMO 2022 Extended anastrozole benefits dependent on tumor characteristics oncology

In this article,

ESMO 2022 Extended anastrozole benefits dependent on tumor characteristics oncology

However, do not use more Arimidex than your doctor recommends. It’s not known if there is a dosage of Arimidex that could cause a life threatening overdose. However, if you have certain side effects of Arimidex, drinking alcohol could worsen them.

With most breast cancers, the abnormal cells are encouraged to grow by the hormone estrogen. (Withdrawal symptoms are side effects that can happen when you stop taking a drug that your body is relying upon.) And stopping Arimidex suddenly (sometimes called “stopping cold turkey”) shouldn’t cause any problems for you. On average, joint pain seems to begin about 6 weeks after starting an aromatase inhibitor.

Side effects and risks

Arimidex is a type of hormone therapy called an aromatase inhibitor. It works by stopping estrogen from being made in your body by the aromatase enzyme. On the other hand, tamoxifen is a type of hormone therapy called a selective estrogen receptor modulator (SERM). It works by stopping estrogen from attaching to cancer cells in your body. Some studies found that breast cancer is less likely to come back if an aromatase inhibitor is taken for an additional 5 years after the first 5 years of adjuvant therapy. (Aromatase inhibitors are a class of medications.) With this approach to treatment, the drug would be taken for a total of 10 years.

  • Although there was no prior indication that liver injury could occur in this patient, no other medications and no other causes of liver injury were determined following extensive workup.
  • Results generated with our FBA suggest that atrazine possibly also exerts a direct influence on the ovary (Table 5).
  • Of the patients entered who had prior tamoxifen therapy for advanced disease (58% in Trial 0004; 57% in Trial 0005), 18% of these patients in Trial 0004 and 42% in Trial 0005 were reported by the primary investigator to have responded.
  • Anastrozole has been found to cross the placenta following oral administration of 0.1 mg/kg in rats and rabbits (about 1 and 1.9 times the recommended human dose, respectively, on a mg/m² basis).
  • Secondary endpoints of the trial included distant disease-free survival, the incidence of contralateral breast cancer and overall survival.

This helps prevent others, including children and pets, from taking the drug by accident. If you have trouble swallowing pills, talk with your doctor or pharmacist. This interaction is possible because these supplements contain phytoestrogens, which are weak estrogen-like substances found in certain plants.

What Is the Sentinel Lymph Node in Breast Cancer?

In one study of women with advanced breast cancer, first-line treatment with Arimidex was more effective than first-line treatment with tamoxifen in slowing down cancer growth and spread. However, hormone receptor status wasn’t known for 11% of the women. This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use.

  • Men taking this medication should talk to their providers about the potential for birth defects and the need for contraception.
  • This medication can increase the risk of bone loss (osteoporosis).
  • How long you take Arimidex for early breast cancer will depend on how likely your breast cancer is to come back.
  • Arimidex (anastrozole) is a non-steroidal aromatase inhibitor used to treat breast cancer in postmenopausal women.
  • However, in another study, raised cholesterol levels weren’t reported in women who took Arimidex for just 1 year.

For all doses, Buy Letrozol 2.5 mg USA did not affect cortisol or aldosterone secretion at baseline or in response to ACTH. No glucocorticoid or mineralocorticoid replacement therapy is necessary with anastrozole. During the ATAC trial, more patients receiving ARIMIDEX were reported to have elevated serum cholesterol compared to patients receiving tamoxifen (9% versus 3.5%, respectively) [see ADVERSE REACTIONS].

Alternatives to Arimidex

One randomized controlled study showed improved toxicity profile and likely better pain control in patients randomized to intrathecal therapy. The blood levels of this medication can be affected by certain foods and medications, so they should be avoided. Be sure to tell your healthcare provider about all medications and supplements you take. You should not take this medication if you are currently taking tamoxifen or other medications that include estrogen, including hormone replacement therapy, birth control pills, estrogen creams, vaginal ring, and vaginal suppositories.

Anastrozole is a medication used in the management and treatment of breast cancer. This activity describes the indications, action, and contraindications for anastrozole as a valuable agent in managing advanced hormone-receptive breast cancer. Anastrozole is a non-steroidal aromatase inhibitor used to treat estrogen receptor-positive breast cancer in postmenopausal women. A case report describes a 58-year-old woman presented with significantly elevated liver enzymes 4 years after anastrozole initiation.


If you have questions about using medications that contain estrogen with Arimidex, talk with your doctor. Below are lists of medications that can interact with Arimidex. These lists do not contain all the drugs that may interact with Arimidex. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Arimidex can lower your estrogen level by about 70% after 24 hours following your dose of the drug.

Endocrine Therapy for Breast Cancer

RxList does not provide medical advice, diagnosis or treatment. This is not a list of all drugs or health problems that interact with this drug. The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Inhibition of aromatase prevents the synthesis of oestrogens. Patients should be informed that an increased level of cholesterol might be seen while receiving Anastrozole.

Leave a Comment